摘要
目的:研究血浆纤维蛋白原浓度与冠心病（CHD）之间的关系。方法:选择610例行冠状动脉造影者,测定血浆纤维蛋白原（FIB）水平,观察冠心病患者冠状动脉狭窄程度与FIB水平变化的直线相关性。结果:（1）350例CHD患者FIB水平明显高于260例冠状动脉正常者[（3.86±0.87）g/Lvs（2.76±0.72）g/L,P<0.01];FIB随狭窄支数增加有增高趋势,但亚组之间差异无显著性。（2）FIB水平与冠脉狭窄程度间呈轻度直线性相关（r=0.225,P<0.01）。（3）FIB水平对CHD的预测价值以FIB≥3.5g/L为界,其敏感性为53.7％,特异性为80.8％。结论:冠心病患者血浆纤维蛋白原浓度增高是冠状动脉血栓形成的主要原因之一,但未发现其与冠状动脉狭窄程度明显相关。
Objective: To study the relationship between level of plasma fibrinogen(FIB) and coronary heart disease (CHD) .Methods: Levels of plasma FIB were detected in 610 patients who underwent the examinations of coronary angiography. The linear relationship between level of FIB and the branch number or degree of coronary stenosis was analyzed. Results: (1) The levels of plasma fibrinogen were higher in 350 patients with CHD than that in 260 patients without CHD[ (3.86 + 0.87)g/L and (2.76 + 0.72)g/L respectively, P<0.01) ]. There was an increased trend in FIB with the increase of branches of stenosis. (2)There was a slight relation between FIB and coronary stenosis (P<0.01) . (3) The threshold of the prediction of CHD was FIB≥3. 5 g/ L. The sensibility was 53.7%, and the specificity was 80.8%. Conclusion: The increase of plasma fibrinogen is a main reason in the formation of CHD, but the significant correlation between FIB and coronary stenosis is not found.
出处
《天津医药》
CAS
北大核心
2002年第8期472-474,共3页
Tianjin Medical Journal
