摘要
目的:评估潘妥洛克联合呋喃唑酮在幽门螺杆菌(Helicobactor pylori,H.pylori)根治治疗中的作用.方法:480例H.pylori阳性患者随机分为4组.分别为三联疗法(潘妥洛克+阿莫西林+呋喃唑酮)7 d组(A组)、10 d组(B组),四联疗法(潘妥洛克+阿莫西林+呋喃唑酮+果胶铋)7d组(C组)、10 d组(D组).根据意向性治疗分析(intension-to-treat,ITT)和试验方案(per protocal,PP)进行分析,采用治疗方案的成本-效果(cost-effectiveness,C-E)分析,p<0.05为差异具有统计学意义.结果:A组及B组的H.pylori根除率分别为71.2%及80.9%,组间比较无统计学意义(P>0.05).C组及D组的H.pylori根除率分别为83.1%及85.3%,组间比较差异无统计学意义,所有4组中D组根除率85.3%,最高,与A组相比有差异有统计学意义(P<0.05).结论:潘妥洛克联合呋喃唑酮可有效提高H.pylori的根除率,在发展中国家可作为一线方案推荐使用.
AIM：To evaluate the effects of pantoprazole combined with furazolidone in Helicobacter pylori（H.pylori） eradication therapy.METHODS：Four hundred and eighty enrolled patients with H.pylori infedton were randomly divided into four groups：A,B,C and D.Group A received pantoprazole ＋ amoxicillin ＋furazolidone for 7 d,and group B received the same triple therapy for 10 d.Group C received pantoprazole ＋ amoxicillin ＋ furazolidone ＋bismuth pectin for 7 d,and group D received the same quadruple therapy for 10 d.Intension-totreat（ITT） and per protocol（PP） analyses were used to compare the eradication rates among these groups.RESULTS：H.pylori eradication rate was71.2%in group A and 80.9%in group B,and there was a significant difference between the two groups（P 〉 0.05）.H.pylori eradication rate was 83.1%in group C and 85.3%in group D,and there was no significant difference between the two groups（P 〉 0.05）.The H.pylori eradication rate in group D was the highest among the four groups,and there was a significant difference between groups A and D（P 〈 0.05）.CONCLUSION：Furazolidone-based quadruple therapy can effectively improve the H.pylori eradication rate.The therapy can be recommended as first-line choice for H.pylori eradication in developing countries.
出处
《世界华人消化杂志》
CAS
2015年第5期866-870,共5页
World Chinese Journal of Digestology
关键词
幽门螺杆菌
潘妥洛克
呋喃唑酮
四联疗法
Helicobacter pylori
Pantoprazole
Furazolidone
Quadruple therapy
