摘要
目的 观察化疗前后卵巢癌患者外周血T淋巴细胞亚群和NK细胞的变化 ,探讨化疗对患者的免疫损伤情况。方法 用流式细胞仪检测患者化疗前后外周血T淋巴细胞亚群和NK细胞的百分率。结果 与正常人比较 ,不论化疗前或化疗后 ,各指标均显著下降 ,有统计学意义。化疗后与化疗前比较 ,CD+ 4细胞和NK细胞明显下降 ,差异有统计学意义 ,CD+ 8细胞在前两个疗程变化不明显 ,第 3疗程下降明显 ,有统计学意义 ,后三个疗程变化虽没有统计学意义 ,但有下降趋势。CD+ 4/CD+ 8比值在第 3疗程比化疗前升高 ,其它 5个疗程均有下降 ,均有统计学意义。结论 卵巢癌患者免疫状态比正常人低 ,化疗对患者免疫功能的影响主要是对CD+ 4细胞和NK细胞的损伤 。
Objective To observe the changes in peripheral blood T lymphocyte subset and NK cell before and after chemotherapy in patients with ovarian carcinoma,and to explore the effect of chemotherapy on immune function.Methods T lymphocyte subset and NK cell were measured by flow cytometry.Results Compared with the normal women,all of the value in CD + 4 cell and NK cell were cut down significantly both before and after the chemotherapy.Compared with the value before chemotherapy,the T lymphocyte subset and NK cell were decreased significantly.The CD + 8 cell did not change significantly during the first two cycles,but it did in the third cycle.Though there were no statistically significant differences during the last three cycles,there were tendencies towards descending.CD + 4/CD + 8 proportion increased in the third cycle,but decreased in other five cycles.All changes were statistically significant.Conclusion Basic immune function of patients with ovarian carcinoma was lower than that of normal women.The influence of chemotherapy on cellular immune function is that CD + 4 cell and NK cell are damaged.Determination of the peripheral blood T lymphocyte subset and NK cell plays an important role in predicting the patients′ immune state.
出处
《中国肿瘤临床与康复》
2002年第4期58-60,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
