摘要
本文对22例应用庆大霉素和4例应用庆大霉素加先锋必的新生儿,进行了三种尿酶、尿比重、尿素氮以及血、尿β_2微球蛋白的测定,且作了用药前后的对比,结果表明庆大霉素可造成新生儿肾功能损害,不宜作为临床首选药物,必须严格掌握适应症,对庆大霉素加头孢霉素类药物合并使用更应谨慎。为早期发现药物的肾脏毒性作用,我们推荐新生儿在应用庆大霉素或其它肾毒作用的药物时,监测尿中NAG和LZM活性。
This Study ohserved 22 neonatal infants given gentamicin and 4 given gen- tamicin and cefobid whose 3 kinds of urinary enzymes,urinary specific gravi- ty,blood urea nitrogen and β_2-microglobulin in blood and urine were examined. The results before using the drug were compared with it after using drug.We found that gentamicin can injure the renal function of neonatal infants.There- fore,it is not suitable that gentamicin was used as the first choise drug.If it is used,indications must cautiously followed.Gentamicin and cefobid were used simultaneouly arid with greater care.In order to found early nephrotoxicity of the drug,we suggest that N-β-D-glucosaminidase and lysozyme in urine should be examined when gentamicin or other nephrotoxic drug are used.
关键词
庆大霉素
肾脏
副作用
儿童
gentamicins/AE
kidney function test
child
