摘要
[目的]探讨脑胶质瘤中转化生长因子β2 (TGF_β2)蛋白的表达与PCNA标记指数(PCNALI)及预后的关系。[方法]根据WHO分类标准进行分类 ,应用免疫组化方法 (EnVisionSystem二步法 )对58例胶质瘤和9例正常脑组织石蜡标本进行TGF_β2 和PCNA蛋白的检测并随访 ,比较患者1年生存率。[结果]TGF_β2 蛋白和PCNA在胶质瘤细胞中有不同程度的表达,表达强度跟肿瘤的恶性程度相关。TGF_β2 蛋白表达强弱和PCNALI高低反映患者的预后。[结论]胶质瘤能够不同程度地表达PCNA和TGF_β2 ,胶质瘤的恶性程度不但体现在其高度增殖的生物学状态中 。
To investigate the expression of TGF-β2 and PCNA in gliomas and its relationship to patients' prognosis. Fifty-eight gliomas were classified according to WHO classification.TGF-βand PCNA were detected by immunohistological stain.All patients were followed up.Expression of TGF-β2 and PCNA was significantly positive in gliomas. The expression of TGF-β2 and PCNA was related to gliomas' grade and patients' prognosis. [Conclusion]Glioma cells can express PCNA and TGF-β2 . The malignancy of glioma embodies not only in its status but also in its behaviors.
出处
《肿瘤学杂志》
CAS
2002年第2期84-86,共3页
Journal of Chinese Oncology
关键词
神经胶质瘤
转化生长因子
增殖细胞核抗原
预后
glioma
transforming growth factor
proliferative cell nuclear antigen
prognosis
