摘要
目的 对比观察 7 5 %高渗氯化钠溶液 (HTS)对人类前列腺素E2 (PGE2 )、IL 2和IL 6的影响 ,探讨其对人体免疫功能的调节作用及可能机制。方法 随机将 40例ASAⅠ～Ⅱ级择期手术病人分为两组 (每组 2 0例 ) :A组在麻醉前输入 7 5 %HTS 4ml/kg ;B组在麻醉前输入等量的复方氯化钠溶液 ,随后均以复方氯化钠溶液维持循环稳定。分别于输液前 (T1)、输液后 1 5小时 (T2 )和输液后 2 4小时 (T3 )取血测PGE2 、IL 2和IL 6。结果 A组病人在T3 时PGE2 明显降低 (P <0 0 1) ;与B组比较 ,A组IL 2、IL 6有上升趋势 ,但无统计学意义。结论 高渗氯化钠溶液可以降低血PGE2 水平。
Objective To observe the effects of 7 5% hypertonic sodium chlorid solution (HTS) on human prostaglandin E 2 (PGE 2),interleukin 2 (IL 2) and interleukin 6(IL 6).Methods 40 ASAⅠ～Ⅱ elective surgical patients were randomly divided to two groups.Before anesthesia,4ml/kg of 7 5% HTS was infused in 20 cases (HTS group) and a same amount of compound injection of sodium chloride were given to other 20 cases (control group).The blood samples were taken for the measurements of PGE 2, IL 2 and IL 6 before the infusion (T 1),at 1 5h (T 2), and 24h (T 3) after the infusion respectively.Results The HTS group showed an obviously decreased in PGE 2 ( P< 0 01) at T 3,and an tendency of rise in IL 2 and IL 6 compared to the control group.Conclusion HTS significantly decreases the PGE 2 level postoperatively.
出处
《临床麻醉学杂志》
CAS
CSCD
2001年第12期657-659,共3页
Journal of Clinical Anesthesiology
