摘要
蛋白酶体是普遍存在于所有被检测过的细胞中的一种保守的蛋白酶复合物 ,有着广泛的功能。它在 MHC- 类抗原的加工呈递过程中起着非常重要的作用 ,而 MHC- 类抗原的加工呈递效率对肿瘤和胞内感染性疾病的防治特别重要 ,因此 ,本文对蛋白酶体的结构、MHC-
Proteasome is one kind of conserved proteases existing ubi quitously in all detected cells and has many functions It plays a key role in the processing and presentation of MHC Ⅰ restricted anti gens Due to the important role of MHC Ⅰ restricted antigen in the defense and treatment of carcinoma and intracellular infection, herein the structure, the role in the processing and presentation of MHC Ⅰ restricted antigen and the molecular mechanism of proteasome is sum marized
出处
《免疫学杂志》
CAS
CSCD
北大核心
2001年第5期391-395,共5页
Immunological Journal
关键词
蛋白酶体
MHC-I
抗原
呈递
proteasome
major histocompatibility class Ⅰ
antigen
presentation
