摘要
1981～1988年间曾对100例Dukes B,C和A_3期直肠癌患者进行了术前经直肠腔的5-Fu辅助化疗,每次200mg,平卧保留3小时以上,每日2次,直至术前1天,平均给药22天,总量8.8g,并随机选择同时期、情况基本相同和未进行术前化疗的直肠癌患者100例作为对照组,术后随访2～8年。术前辅助化疗组局部复发率为15％,而对照组为26％,有显著差异(p<0.05)。因此我们认为对Dukes B,C和A_3期直肠癌病人,在放疗设备不够满意的地区和单位,病人在等待住院和术前准备期内应进行经直肠腔的5-Fu辅助化疗,以减少术后局部复发。
Preoperative intrarectal 5-FU adjuvant chemotherapy was employed for 100 DukesB, C and A_8 (Chinese modification) rectal cancer patients between 1981～1988. Another100 rectal cancer patients, treated during the same period without preoperative chemo-therapy, were served as controls. The sex, age, tumor types, Broder's classificationand Dukes' staging in the two groups were comparable. All patients had been followedfor 2～8 years. The rate of local recurrence in the group with intrarectal 5-FU was15%, and that in the control group, 26% (p<0.05). This demonstrates the potentialvalue of preoperative intrarectal 5-FU adjuvant chemotherapy in reducing postopera-tive local recurrence.
出处
《肿瘤》
CAS
CSCD
北大核心
1993年第1期1-3,共3页
Tumor
基金
卫生部"六
五"恶性肿瘤重点资助课题
