摘要
雪旺细胞是周围神经系统特有的神经胶质细胞,也是髓鞘形成细胞,能提供多种细胞因子和营养因子支持受损轴突再生并通过增殖分化形成髓鞘包绕新生轴突。神经干细胞是神经系统发育过程中保留下来的具有多向分化潜能的原始细胞,具有免疫原性低、组织融合性好、可自我更新等特点。雪旺细胞与神经干细胞对于外周神经损伤的修复与再生有着重要作用。近来随着显微外科技术的发展,利用神经导管联合神经干细胞与雪旺细胞桥接神经断端以实现周围神经损伤的修复吸引了越来越多研究者的兴趣。
Neural stem cells（NSCs）and Schwann cells（SCs）both play an important role in the recovery and regeneration of peripheral nerve injury,which makes them become the focus in the field of nerve injury research.SCs provide a suitable microenvironment for the recovery and regeneration of injured peripheral nerve through secreting various cytokines and other related factors,and they can significantly promote the differentiation of NSCs into neurons.Recently with the development of microsurgical technique,using nerve conduits along with NSCs and SCs to bridge nerve stumps so as to repair peripheral nerve injury has now attracted increasing research interest.In this article,we focus on the effects and mechanisms of NSCs and SCs on peripheral nerve injury and regeneration process,and describe the future trend and potential clinical application of the technology combining both two cells and nerve conduits to repair peripheral nerve injury.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2014年第13期1006-1009,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
2013年上海交通大学王宽诚医学奖励基金资助
关键词
神经干细胞
雪旺细胞
神经损伤
神经导管
修复
neural stem cells
Schwann cells
nerve injury
nerve conduit
repairing
