摘要
目的探讨经导管动脉硬化栓塞术治疗Kasabach-Merritt综合征(KMS)的疗效。方法收集经超声、CT、生化检查结合临床表现确诊的KMS患儿58例,纠正血小板减少及凝血功能异常后,给予经导管动脉硬化栓塞术进行治疗。结果对所有患儿均顺利完成经导管动脉硬化栓塞术,术后动脉造影见瘤体基本消失;术后1周血小板[(267.66±61.50)×109/L]和纤维蛋白原[(2.64±0.40)g/L]水平均明显高于术前[血小板:(35.24±12.12)×109/L,纤维蛋白原:(1.47±0.33)g/L],差异有统计学意义(P均<0.01);44例患儿接受1次经导管动脉硬化栓塞术、11例接受2次经导管动脉硬化栓塞术、3例接受3次经导管动脉硬化栓塞术;所有患儿均达治愈标准。结论经导管动脉硬化栓塞术治疗KMS安全、有效,值得临床推广应用。
Objective To evaluate the effect of transarterial embolization in treatment of Kasabach-Merritt syndrome （KMS）. Methods Totally 58 children patients with KMS confirmed by ultrasound, CT and biochemical examination combined clinical manifestations received transarterial embolization after correcting the thrombocytopenia and dysfunction of coagulation. Results The transarterial embolization was successfully performed in all the cases and the angeiomas almost disappeared in postoperative angiography. One week after transarterial embolization the platelet counts （[267.66±61.50] × 109/L） and fibrinogen （[-2. 64± 0.40]g/L） both significantly increased compared with preoperation （platelet counts： [35.24±12.12]× 109g/L, fibrinogen： [1. 47±0.33]g/L, both P〈0.01）. The transarterial embolization was performed for once in 44 cases, for twice in 11 cases and for three times in 3 cases. All the patients got to the criterion of cure. Conclusion Transarterial embolization is safe and effective in treatment of KMS, which has promising prospect.
出处
《中国介入影像与治疗学》
CSCD
2014年第7期415-418,共4页
Chinese Journal of Interventional Imaging and Therapy
