摘要
为探讨广枣总黄酮 (TFC)抗心律失常的作用机制 ,采用竞争性蛋白结合分析法 ,测定心肌组织 c AMP含量和腺苷酸环化酶 (AC)活性。结果表明 ,TFC5 0、10 0、2 0 0μg/ m l均可明显抑制离体大鼠心肌组织中的 AC活性 ,TFC10 0 mg/ L可使c
To approach Mechanism of action of total flavones from fructus of Choerospondias Axillaris (TFC)on antiarrhythmias,We determined cAMP and adenylate cyclase of isolated rat myocardium by competitive protein-binding assay.The results suggest that TFC 50,100,200ug/ml inhibited significantly adenylate cyclase of the rat ventricular myocardium and TFC 100mg/L reduced the level of cAMP in both ischemic and nonischemic myocardium.
出处
《中国民族医药杂志》
2001年第1期34-35,共2页
Journal of Medicine and Pharmacy of Chinese Minorities
基金
国家自然科学基金资助项目 !3 9760 0 83
关键词
广枣总黄酮
离体心脏
CAMP
腺苷酸环化酶
total flavones from fructus of Choerospondias Axillaris
isolated heart
cAMP
adenylate cyclase
