摘要
目的 :对消痤丸进行药效学研究。方法 :用液体—试管法 37℃厌氧培养痤疮丙酸杆菌 72 h,37℃培养金黄色葡萄球菌 18h,定量测定消痤丸最低抑菌浓度 ,并观察其对醋酸所致小鼠腹腔毛细血管通透性及巴豆油致炎剂所致小鼠耳廓肿胀的影响。结果 :消痤丸对痤丙酸肝菌及金黄色葡萄球菌的最低抑菌浓度分别为 0 .12 5 g/m l,0 .2 5 g/ml;消痤丸 1.5 g/kg,3.0 g/kg能非常显著地降低醋酸所致小鼠腹腔毛细血管的通透性亢进 (P<0 .0 1) ;减轻巴豆油致炎剂所致小鼠耳廓的肿胀 (P<0 .0 1)。结论 :消痤丸有明显的抑菌、抗炎作用。
To study the pharmacodynamics of Xiaocuo pills, propinibacterium acnes were anaerobic cultured at 37℃ for 72 hours and staphylococus aureus were cultured at 37℃ for 18 hours with liquid tubal method. The minimum inhibitory concentration of Xiaocuo pill were 0.125 g/ml and 0.25 g/ml by quantitative determination. 1.5 g/kg and 3.0 g/kg of Xiaocuo pill on mice could significantly decrease abdominal capillary permeability induced by acetic acid ( P<0.01) and ease auricle swelling induced by croton oil ( P<0.01). The experimental results indicated Xiaocuo pill had obvious bacteiostatic and anti inflammatory effects.
出处
《时珍国医国药》
CAS
CSCD
2001年第1期15-16,共2页
Lishizhen Medicine and Materia Medica Research
关键词
消痤丸
痤疮丙酸杆菌
金黄色葡萄球菌
抗炎
抑菌
Xiaocuo pill
Propinibacterium acnes
Staphylococus aureus
Anti inflammatory action
Bacteriostatic action
