摘要
目的 测定中枢神经系统 (CNS)转移癌患者脑脊液 (CSF)S 10 0 β蛋白含量 ,并探讨其对CNS转移癌患者脑损伤的评估价值。方法 CNS转移癌患者重度组 7例 ,中度组 10例 ,轻度组 8例 ;2 0例作为正常对照。CSFS 10 0 β蛋白含量采用酶联免疫吸附试验双抗体夹心法检测 ,同时进行CSF细胞学检查。结果 CNS转移癌重度、中度和轻度三组患者CSFS 10 0 β蛋白含量均明显高于对照组(P均 <0 .0 1) ,其中重度组 >中度组 >轻度组 ;重度组患者CSF淋巴细胞比例最低 ,且与对照组和轻度组比较差异有显著性 (P <0 .0 1和P <0 .0 5 )。结论 CNS转移癌患者CSFS 10 0 β蛋白含量高低与脑组织损伤的严重程度呈正相关。
Objective To investigate the concentration of S-100 beta protein in cerebrospinal fluid (CSF) for 25 patients with metastatic carcinoma to central nervous system (CNS), and to evaluate its clinical value. Methods S-100 beta protein of CSF was measured by ELISA for 25 patients with metastatic carcinoma to CNS and 20 patients without any CNS disease (control group). The patients were divided into three categories according to severity of disease: severe group, moderate group and mild group. Meanwhile, CSF cytology was also detected. Results The level of S-100 beta protein of all patients was higher than that of control group( P <0.01), and severe group>moderate group ( P <0.01) > mild group ( P <0.01). The percentage of CSF lymphocyte in severe group was lower than that of mild group and control group ( P <0.05 and P <0.01). Conclusions CSF S-100 beta protein level of patients with metastatic carcinoma may be related to the severity of their brain insult.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2000年第11期732-734,共3页
Chinese Journal of Internal Medicine
