摘要
目的 :研究烧伤后细胞因子的变化规律及其相关性 ,并探讨其临床意义。方法 :采用放射免疫法和ELISA法检测烧伤患者血中TNF、IL 6及IL 8水平。结果 :烧伤后血中TNF、IL 6及IL 8水平均显著高于正常对照组 (P <0 0 0 1) ,且持续时间较长 (4～ 5周 ) ,它们间呈正相关 (P <0 0 1) ;同时 ,IL 6与烧伤总面积呈正相关。结论 :细胞因子活性的检测有助于病情的评估及预后判断 ,尤其是大面积烧伤患者。
Objective:To investigate the changes of cytokines and tle clinical significancl in patients with burns.Methods:RIA and ELISA methods were used to determine the TNF,IL 6 and IL 8 levels in burn patiants.Results:Levels of TNF,IL 6 and IL 8 in burn patients were significantly greater than normal controls(P<0 001),and this was prolonged (4～5weeks).There were significant positive correlations(P<0 01) among TNF and IL 6,TNF and IL 8,and IL 6 and IL 8,and a significantly positive correlation between serum levels of IL 6 and total burn surface area.Conclusion:The assay of TNF,IL 6 and IL 8 levels may be helpful for evaluating patients and the prognosis,particularly for those wih extensive deep burns.
出处
《急诊医学》
CAS
CSCD
2000年第6期387-388,共2页
关键词
烧伤
TNF
IL-6
IL-8
相关性
Burn Tumour necrosis factor Interleukin 6 Interleukin 8
