摘要
目的探讨血清IL-18、IL-6及CRP水平在多囊卵巢综合征患者(PCOS)患者中的变化及其临床意义。方法分别应用酶联免疫吸附法和免疫透射比浊法检测64例PCOS患者血清IL-18、IL-6及CRP含量,并与64例正常对照组比较分析。结果 PCOS患者血清IL-18、IL-6、CRP及HOMA-IR水平较健康对照组升高(P<0.05);且PCOS肥胖型患者血清IL-18、IL-6、CRP及HOMA-IR水平较非肥胖型明显升高(P<0.05);血清IL-18、IL-6、CRP水平与HOMA-IR均呈明显正相关(r=0.639,r=0.657,r=0.708,均P<0.01)。结论 PCOS可能是一种慢性亚临床炎症反应状态,炎症因子的明显增加,导致炎症损伤,并和胰岛素抵抗关系密切,而肥胖可能作为一种慢性亚临床炎症反应加重PCOS的异常。
Objective： To explore the clinical significance of ehanges of serum. IL - 18, IL -6 and CRP in patients with polycys- tie ovarian syndrome （PCOS）. Methods： Serum IL- 18, IL-6 and CRP levels were measured by EL1SA and immunity turbidimetry respectively in 64 patients with PCOS and 64 health control. Results： The PCOS group serum IL - 18, IL -6, CRP levels and HOMA -IR were higher than the healthy control group （P 〈 0. 01 ） ; and the levels of serum IL- 18, IL- 6, CRP and HOMA- IR in endomorph PCOS group were higher than the non - endomorph PCOS group （P 〈 0. 01 ）. The HOMA - IR were positive correlation with the level of IL - 18, IL -6, CRP in patients with PCOS （r =0. 639, r =0. 657, r =0. 708, all P 〈0. 01 ）. Conclusion： PCOS may be a chronic subclinical inflammation status, Inflammation factor increased significantly lead to immune damage, which have a close relation with IR, and Obesity may be the chronic subclinical inflammation status and aggravate the abnormal of PCOS patients.
出处
《中国优生与遗传杂志》
2013年第10期32-33,44,共3页
Chinese Journal of Birth Health & Heredity
