摘要
目的:分析抗菌药物整治前后铜绿假单胞菌耐药率的变化,为有效治疗和控制该菌引起的感染提供参考。方法:用WHONET 5.4软件分析某院2010-2012年共12个季度的铜绿假单胞菌耐药率,以2010年1月-2011年6月为抗菌药物整治前,2011年7月-2012年12月为抗菌药物整治后。用SPSS 16.0对抗菌药物专项整治前后的耐药率进行统计分析。结果:铜绿假单胞菌的耐药率总体呈下降趋势。铜绿假单胞菌对呋喃妥因、环丙沙星、美罗培南、哌拉西林、哌拉西林/他唑巴坦、头孢吡肟、头孢哌酮、头孢哌酮/舒巴坦、头孢曲松、头孢噻肟、头孢他啶、妥布霉素、左氧氟沙星的耐药率在整治前后比较差异有统计学意义(P<0.05)。结论:抗菌药物的合理使用有利于降低细菌对抗菌药物的耐药率;该院抗菌药物专项整治效果显著。
OBJECTIVE： To analyze the resistance rate of Pseudomonas aeruginosa before and after specific rectifications of antibiotics, and to provide reference for effective treatment and control of infection induced by P. aeruginosa. METHODS ： The re- sistance rate of P. aeruginosa was collected and organized for 12 quarters during 2010--2012 by WHONET 5.4 software. The resis- tance rates of P. aeruginosa were statistically analyzed before and after specific rectifications of antibiotics by SPSS 16.0 software during Jan. 2010--Jun. 2012 （before rectification） and Jul. 2011--Dec. 2012 （after rectification）. RESULTS： The resistance rate of P. aeruginosa was decreased on the whole. The resistance rate of P. aeruginosa to 13 antibiotics had statictical significance before and after specific rectifications of antibiotics, such as nitrofurantoin, ciprofloxacin, meropenem, minocycline, piperacillin, pipera- zine piperacillin/tazobactam, cefepime, cefoperazone, cefoperazone/sulbactam, ceftriaxone, cefotaxime, ceftazidime, tobramycin, levofloxacin （P〈0.05）. CONCLUSIONS： Rational use of antibiotics is helpful to reduce resistance rate of bacterical to antibiotics. In the hospital the effect of specific rectifications of antibiotics is significant.
出处
《中国药房》
CAS
CSCD
2013年第42期3978-3980,共3页
China Pharmacy
关键词
抗菌药物专项整治
铜绿假单胞菌
耐药率
Specific rectifications of antibiotics
Pseudomonas aeruginosa
Resistance rate
