摘要
目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAS)患者左室功能情况与OSAS严重程度的关系。方法:对94例经整夜多导睡眠监测确诊为OSAS,且其他方面正常的患者进行超声心动图检测获取左心室结构及功能的超声参数。根据呼吸暂停低通气指数(AHI)将患者分为轻度OSAS组(AHI 10～20次/h)、中度OSAS组(AHI 20～40次/h)和重度OSAS组(AHI≥40次/h)。另取AHI<10次/h者30例为对照组。比较各组超声参数。结果:重度OSAS组左房内径(LAD)、舒张末期室间隔厚度(LVSd)、舒张末期左心室后壁厚度(LVPWd)、收缩末期左心室内径(LVDs)、舒张末期左心室内径(LVDd)与E峰减速时间(EDT)均高于对照组(均P<0.05),但左心室射血分数(LVEF)、左心室缩短分数(FS)及E/A较对照组差异无统计学意义(均P>0.05)。中、重度OSAS组E/Em高于对照组(P<0.05)。Em与LAD、LVSd及LVPWd呈负相关性(r分别为-0.266、-0.241及-0.412)。结论:中、重度OSAHS组患者(AHI≥20次/h)左室功能减退的发生率高,心室功能受损主要表现为舒张功能受损。E/Em比值的变化能可靠地反应患者左室舒张功能受损的程度。
Objective： To investigate the left ventricular （LV） dysfunction in patients with obstructive sleep apnea hypopnea syndrome （OSAS） and examine the relation between severity of OSAHS and LV dysfunction. Method：A total of 94 patients with OSAS were included and classified into three mild OSAS group （AHI 10--20/h）, moderate OSAS group （AHI 20--40/h） and severe OSAS group （AHI≥40/h）. Other 30 patients with AHI≥40/h were included into control group. Echocardiographic parameters were compared in the three groups. Result： In severe OSAS group, LAD, LVSd, LVPWd, LVDs, LVDd and EDT were significantly higher than those in con- trol group （all P〈0.05）, while LVEF, FS and E/A had no statistically significant between the two groups. In moderate and severe OSAS groups, E/Era was higher than that in control group （P〈0.05）. E/Em was negative- ly correlated with LAD, LVSd and LVPWd （r was -0. 266, -0. 241 and -0. 412, respectively）. Conclusion： Patients with moderate and severe OSAS are associated with impaired LV function. The impaired LV global func- tion is demonstrated as diastolic dysfunction. E/Em could be identified as the best index to detect diastolic dys function.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2013年第10期775-777,共3页
Journal of Clinical Cardiology
关键词
睡眠呼吸暂停
阻塞性
左室功能
sleep apnea
obstructive
left ventricular function
