摘要
半胱天冬氨酸酶(caspase)普遍存在于真核生物,在细胞凋亡中具有重要作用,广泛参与胚胎发育、炎症反应、器官发生、变态过程及自稳态维持等多种生理过程。caspase级联反应将细胞外信号传递到细胞内,水解底物蛋白或激活转录因子发挥作用。目前,细胞凋亡通路在哺乳动物的作用机制已有大量的报道,但对水生无脊椎的研究相对较少。综述caspase细胞凋亡通路及其在水生无脊椎动物的研究进展。
Caspases exist in all eukaryotic cells and play important a role in cell apoptosis.They are widely involved in embryonic development,inflammation,organogenesis,metamorphosis,homeostasis and other physiological processes.Caspases transduce signals from outside to the cytoplasm or nucleus by a conserved caspase cascade,hydrolyzing intracellular substrate proteins or activating transcription factors to regulate physiological processes.Currently,most of the knowledge about the mechanisms of the caspase-apoptosis pathway focuses on the mammalian system.So far,basic knowledge of the caspase-apoptosis pathway in aquatic invertebrates is limited.In this article,combined data collected in our laboratory,we reviewed the research advance on caspase-apoptosis pathway in aquatic invertebrates to date.
出处
《生物技术通报》
CAS
CSCD
北大核心
2013年第9期54-61,共8页
Biotechnology Bulletin
基金
国家自然科学基金项目(41006105
41176152)
福建省科技计划重点项目(2011N0022)
