摘要
基于超临界CO2技术制备的甲氨蝶呤纳米粒为小分子模型药物,采用高压静电抗溶剂法制备甲氨蝶呤-聚乳酸复合微球。用扫描电镜(SEM)、傅立叶红外光谱仪(FT-IR)对该载药复合微球进行表征,并研究其载药量、包封率和药物释放曲线。实验结果表明,甲氨蝶呤-聚乳酸复合微球表面光滑,粒径分布范围在10～50μm之间;FT-IR表明,在高压静电抗溶剂过程中聚乳酸化学结构无变化,有利于其作为药物载体;随着理论载药量增加(2.5%、5%和10%),包封率减少(18.0%、7.1%和2.3%);甲氨蝶呤从聚乳酸微球中释放具有长效缓释的性能,无突释效应。
Using the supercritical CO2 technology-based methotrexate （MTX） nanoparticles as small molecular drug model, the MTX-loaded poly （L-lactide） （PLLA） microspheres were prepared by a high-voltage electrostatic antisolvent process. The resulting MTX-loaded PLLA microspheres were characterized by scanning electronic microscopy （SEM） and Fourier transform infrared spectrophotometry （FT-IR）, and their drug load, encapsulation efficiency and drug release profiles were also investigated. The results show that the MTX-loaded PLLA microspheres have a smooth surface with a mean size range from 10 μm to 50μm; Fourier transform-in- frared （FT-IR） spectra revealed that no alteration of chemical structure occurred during the high-voltage electrostatic antisolvent process, which is favorable for drug carries; with an increase in theoretical drug load （2.5%, 5.0%, and 10.0%）, the encapsulation efficiency decreased （18. 0%, 7.1%, and 2.3%, respectively）; the MTX-loaded PLLA microspheres released the drug with a long sustained-release effect without a burst release.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2013年第10期1409-1413,共5页
Journal of Functional Materials
基金
国家自然科学基金资助项目(51103049
81171471
31170939)
关键词
高压静电抗溶剂
甲氨喋呤
聚乳酸
长效缓释
high-voltage electrostatic antisolvent
methotrexate
poly （L-lactide） microspheres
long sustained-release
