摘要
目的探讨彩色多普勒超声对糖尿病肾病患者颈动脉结构及血流动力学改变的检测价值。方法应用彩色多普勒超声检测158例糖尿病肾病患者(糖尿病肾病组)及123例糖尿病患者(对照组)颈动脉内、中膜厚度(intima-media thickness,IMT)、斑块发生率、血流收缩期峰值流速、舒张末期血流速度、阻力指数(resistanceindex,RI)。比较糖尿病肾病组与对照组以及糖尿病肾病组早中期亚组、中晚期非透析亚组及透析亚组间上述指标的差异。结果糖尿病肾病组颈动脉IMT、斑块发生率明显高于对照组,差异有统计学意义[0.69(0.62～0.78)mm vs.0.56(0.51～0.69)mm,P<0.05;81.0%vs.47.2%,χ2=35.4,P<0.05];糖尿病肾病组中早中期亚组、中晚期非透析亚组及透析亚组3组间随着疾病的发展,颈动脉IMT、斑块发生率也逐渐增加;且透析亚组颈总动脉内径与早中期亚组对比明显增厚,差异有统计学意义[7.36(6.79～7.80)mm vs.7.01(6.36～7.31)mm,P<0.05]。糖尿病肾病组颈动脉舒张末期血流速度减小、RI增大,与对照组相比,差异有统计学意义(P<0.05)。结论糖尿病肾病患者普遍存在颈动脉结构及血流动力学改变,应用彩色多普勒超声检测颈动脉粥样硬化的发生与发展对预测糖尿病肾病患者发生心、脑血管事件具有重要意义。
Objectives To evaluate the value in detection of carotid structure and hemodynamie changes in patients with diabetic nephropathy by color Doppler ultrasound. Methods Carotid artery diameter, intima-media thickness （IMT）, incidence of plaque, peak systolic velocity （PSV）,end diastolic velocity（EDN）, resistance index （RI） were measured by uhrasonography in 158 patients with diabetic nephropathy （experimental group） and 123 patients with diabetes （control group）. The above-mentioned indexes were compared between experimental group and control group, and also among early- medium stage subgroup, medium-advanced stage without dialysis subgroup and dialysis subgroup from experimental group. Results IMT and incidence of plaque of carotid in experimental group were significantly higher than those in control group [0.69 （0.62-0.78） mm vs. 0.56 （0.51-0.69） ram, P〈0.05; 81.0% vs. 47.2%, χ2=35.4, P〈0.001, P〈0.05]. IMT and incidence of plaque of carotid in early-medium stage subgroup, medium-advanced stage without dialysis subgroup, and dialysis subgroup elevated gradually; moreover, carotid artery diameter of dialysis subgroup was significantly thicker than that of early-medium stage subgroup [7.36（6.79-7.80） mm vs. 7.01 （6.36-7.31） mm, P〈0.05]. EDV obviously decreased and RI significantly increased in experimental group comparing with control group （P〈0.05）. Conclusions Carotid artery structure and hemodynamic changes generally exist in patients with diabetic nephropathy. It is important to forecast cardiac and cerebrovascular events in patients with diabetic nephropathy by color Doppler ultrasound.
出处
《岭南心血管病杂志》
2013年第2期189-192,共4页
South China Journal of Cardiovascular Diseases
关键词
颈动脉病变
彩色多普勒
糖尿病肾病
超声
carotid artery lesion
color Doppler
diabetic nephropathy
ultrasonography
