4-羟基-α-氰基肉桂酸衍生物的设计合成及在质谱法手性识别氨基酸中的应用(英文) 被引量：1

Design,synthesis of 4-hydroxyl-α-cyanocinnmaic acid derived compounds and their applications in chiral recognition of amino acids by mass spectrometry

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摘要设计合成了4对以脯氨酸和4-羟基-α-氰基肉桂酸(CHCA)为骨架、作为手性选择子的化合物。通过ESI-MS/MS质谱方法研究氨基酸与手性识别子所形成的质子化二聚体和三聚体,评估了这些化合物对19种氨基酸的手性识别作用。探讨了手性识别子结构变化对氨基酸手性识别作用的影响。 Four pairs of compounds designed based on scaffolds of proline and 4-hydroxy-α-cyanocynnmaic acid （CHCA） have been synthesized as the chiral selectors. Chiral recognition of these compounds towards 19 common amino acids was evaluated by investigating the ESI-MS/MS spectra of the protonated dimers and trimers formed between the amino acids and the chiral selectors. Effects of the structural change of the chiral selectors on chiral recognition towards the amino acids were discussed in this study.

作者罗小雨王海星张舒陈鹏郑欢欢陈河如姚钟平

机构地区暨南大学药学院中药及天然药物研究所手性科学国家重点实验室广东省中药药效物质基础及创新药物研究重点实验室

出处《暨南大学学报（自然科学与医学版）》 CAS CSCD 北大核心 2013年第1期106-114,共9页 Journal of Jinan University(Natural Science & Medicine Edition)

基金 National Natural Scientific Foundation of China(81172982) Science and Technology Project of Guangdong Province(2010A030100006)

关键词手性识别质谱氨基酸脯氨酸 4-羟基-α-氰基肉桂酸 Chiral recognition mass spectrometry amino acid proline 4-hydroxy-α-cyanocynnmaic acid

分类号 R914.5 [医药卫生—药物化学]

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