摘要
目的观察山莨菪碱联合血浆置换(PE)干预血栓性血小板减少性紫癜(TTP)后血小板(PLT)变化情况。方法选择60例TTP患者随机分组,联合干预组30例予山莨菪碱联合血浆置换(PE),疗程21天;对照组30例予以PE干预,疗程21天。结果联合干预组21天后有效率93%,对照组有效率90%,差异有显著性(P<0.05),血小板(PLT)在治疗后第2、5、12数值上升速度明显快于对照组,差异有显著性(P<0.05),有统计学意义,第21天,差异无显著性(P>0.05)。结论血浆置换联合山莨菪碱注射液对血栓性血小板减少性紫癜血小板数值恢复加快,可以判断患者的预后。
Objective To investigate the clinic efficacy and safety of plasma exchange （PE） combined with aniso- damine administration in the treatment of thrombotic thrombocytopenic purpura （TTP）. Methods 60 patients were randomized into two groups,each group contained 30 patients,the treatment group is given anisodamine injection com- bined with plasma exchange（PE） ,and the period of treatment is 21 days; the controlled group is just given plasma ex- change and the period is also 21 days. Results The efficacy of the combined treatment group for 21 days is 93%, the controlled group is 90 % ,there were significant difference between tow groups（P〈0.05）. The speed of the ascension of platelet after treatm.ent for 2,5 and 12 days is obviously more rapid than the controlled group, there were significant difference（P〈0.05） ,and there is statistic meaning. However the contrast of the result of the 21st day shows no signifi- cant difference （P〉0.05）. Conclusion Anisodamine combined with plasma exchange shows better clinic effect and no more hemorrhagic risk than plasma exchange in therapy of thrombotic thrombocytopenic purpura.
出处
《中国实验诊断学》
2013年第2期314-316,共3页
Chinese Journal of Laboratory Diagnosis
关键词
血栓性血小板减少性紫癜
血浆置换
血小板
山莨菪碱
Thrombotic thrombocytopenic purpura
Therapeutic plasma exchange
platelet
Anisodamine
