摘要
目的观察同种异体骨混合自体骨复合骨形态发生蛋白一2（BMP-2）修复胫骨骨缺损的临床疗效。方法采用同种异体骨混合自体骨复合BMP_2修复胫骨骨缺损17例，其中内固定术后骨不连硬化骨去除后骨缺损11例，感染性骨折不愈合去除感染骨后骨缺损6例，均采用植骨结合髓内、外固定治疗，术后1、3、6个月、1年复查x线评价骨折愈合情况，并采用Johner—Wruhs评分评估治疗效果。结果所有患者平均随访14个月（10—38个月）。骨缺损均得以修复，骨折愈合，无感染复发，创面均闭合。Johner-Wruhs评分优良率为94％。结论同种异体骨混合自体骨复合BMP一2所构成的“三合一”植骨模式，在修复胫骨骨缺损中来源广泛、成骨可靠、安全性高。
Objective To evaluate the repair of the tibia] bone defect with allograft bone and auto- graft bone combined with bone morphogenetic protein-2 （BMP-2）. Methods From Feb. 2008 to Feb. 2011, 17 cases accepted reconstruction of tibia] bone defect with allograft bone and autograft bone com- bined with BMP-2, including 11 cases of tibia] bone defect caused by removing the sclerotic bone at the nonunion part after fracture fixation, and 6 cases of tibial bone defect from bone infection nonunion. All of them were treated by bone grafting and internal or external fixation. X-tray was taken to evaluate the bone healing at 1 st, 3rd, 6th and 12th month after operation. The function of the affected extremity was assessed by Johner-Wruhs grade. Results All of the cases were followed up for 14 months （ 10-38 months） postop- eratively. The bone defects and bone fracture healed in all cases without infection. The excellent and good rate according to Johner-Wruhs grade was 94%. Conclusion The ＂ three in one＂ mode of bone grafting with a]lograft bone and autograft bone combined with BMP-2 is safe and reliable in reconstruction of tibia] bone defect.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2013年第2期394-396,共3页
Chinese Journal of Experimental Surgery
基金
武汉市卫生局临床医学科研项目（WX09C12）
