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基底细胞样乳腺癌38例临床病理观察

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摘要 目的:通过对基底细胞样乳腺癌镜下特点,免疫表型的观察,探讨基底细胞样乳腺癌的临床病理特征。方法:采用HE切片观察和免疫组化染色及随访患者的方法,总结基底细胞样乳腺癌的临床病理特征。结果:38例患者,年龄31~78岁,中位年龄54.5岁,组织形态上为富于细胞的实团状,片状,巢状,间质较少,无腺管形成,地图状坏死,推挤性边界,淋巴细胞浸润常见,分级Ⅱ-Ⅲ级,淋巴结转移少见,局部复发远处转移常见,免疫组化均表达ER(-)、PR(-)、HER2(-)、CK5/6(+),38例中有22例随访1~3年,有6人死于乳腺癌。结论:乳腺癌检测CK5/6,同时结合ER,PRHER2的表达情况具有重要临床意义,三连阴及CK5/6(+)的基底细胞样乳腺癌,分级高,复发转移早,预后差。
作者 王仪
出处 《中国社区医师(医学专业)》 2013年第2期225-226,共2页
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参考文献5

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