摘要
采用石墨炉原子吸收光谱(GFAAS)法测定不同类别中药材中的镉,并研究其中镉元素的分布规律及限量控制措施。通过优化微波消解法的消化试剂,使9类中药材不同用药部位均完全消解;以2%磷酸二氢铵溶液为基体改进剂,进行方法学考察。镉元素在0～2 ng/ml浓度范围内线性关系良好。低、中、高浓度样品的回收率为81.2%～97.4%,RSD<9%。测定了23种中药材中的镉,GFAAS法与电感耦合等离子体质谱法(ICP-MS)方法测定结果的相对平均偏差≤20%。不同用药部位中药材镉残留量依次为:动物类叶类全草类花类茎类皮类果实类根类种子类。
A graphite furnace atomic absorption spectrometry （GFAAS） method was established for the determination of cadmium residue in different traditional Chinese medicines （TCMs）. The distribution of cadmium and its limited control measures in different TCMs were studied. The samples were digested by microwave with the optimized acid mixture, which could make all different kinds of TCMs completely digested. The 2 % ammonium dihydrogen phosphate solution was selected as the matrix modifier. It was linear in the concentration range of 0 - 2 ng/ml. The recoveries of the samples with low, medium and high concentration were 81.2% - 97.4%, with RSDs less than 9%. The cadmium in 23 kinds TCMs was detected. The relative deviation between GFAAS and inductively coupled plasma-mass spectrometry （ICP-MS） was within 20 %. The distribution of cadmium in different types of TCMs was as follows： animal medicine〉leaf〉whole herb〉flower〉rhizome〉peel〉fruit〉root〉seed.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2013年第2期180-185,共6页
Chinese Journal of Pharmaceuticals
基金
国家科技部重大新药创制(2009ZX9502-024)
