摘要
目的探讨非小细胞肺癌发生脑转移的高危因素及对生存的影响。方法 回顾对比分析150例经病理确诊的ⅡA～Ⅳ期非小细胞肺癌患者,其中发生脑转移的100例,未发生脑转移者50例,比较两组之间临床特征及肿瘤特征的差异。结果 (1)单因素分析发现,年轻、非鳞状细胞癌、中央型肺癌、有淋巴结转移、肺内播散、合并其他部位转移及未接受治疗是非小细胞肺癌发生脑转移的可能危险因素;多因素分析发现,年龄与病理类型是非小细胞肺癌发生脑转移的高危因素。(2)性别、民族及肺内病变左右位置不是非小细胞肺癌发生脑转移瘤的危险因素。(3)脑转移组中位生存时间为(6.661±0.573)月,低于非脑转移组的(13.318±0.966)月(P=0.000);脑转移组的6月、12月生存率分别为32.0%、14.7%,明显低于非脑转移组的80.6%和62.4%(P=0.000)。结论 年龄<60岁、非鳞状细胞癌是非小细胞肺癌发生脑转移的高危因素,中央型肺癌、肺内转移、淋巴结转移、其他部位远处转移及未接受治疗为非小细胞肺癌患者发生脑转移的可能高危因素。脑转移的发生影响非小细胞肺癌患者的预后。
Objective To analyse the risk factors and survival of non-small cell lung cancer with brain metastasis. Methods One hundred and fifty cases of pathologically confirmed 11 A ～ IV stage patients with non-small cell lung cancer,including 100 cases of brain metastasis and 50 of non-brain metastasis, were retrospectively analysed. Differences of clinical features and tumor characteristics were compared between the two groups. Results （1）The univariate analysis found that younger patients, non-squamous cell carcinoma, central lung cancer, with lymph node metastasis, intrapulmonary spread, with other parts of the transfer and untreated nonsmall cell lung cancer were possible risk factors of brain metastasis. Multivariate analysis found that age and pathological type of nonsmall cell lung cancer were risk factors of brain metastasis. （ 2 ） Gender, nation and location around the pulmonary lesion in non-small cell lung cancer were the risk factors of brain metastasis. （3）The median survival time of brain metastasis group [ （6. 661 ± 0. 573 ） months] ,was lower than that of non-brain metastasis group [ （13. 318 ± 0. 966） months ]. The 6-month, 12-month survival rates of brain metastasis group and non-brain metastasis group were 32. 0%, 14. 7%, and 80. 6%, 62. 4% , respectivly （ P = 0. 000 ）. Conclusions Age 〈 60 years, non-squamous cell carcinoma are the risk factors of non-small cell lung cancer with brain metastases. Central lung cancer,pulmonary metastasis, lymph node metastasis, other parts of distant metastasis and untreated non-small cell lung cancer patients may be the possible risk factors for brain metastasis. The occurrence of brain metastasis may influence the prognosis of patients with non-small cell lung cancer.
出处
《实用肿瘤杂志》
CAS
2013年第1期45-49,共5页
Journal of Practical Oncology
关键词
癌
非小细胞肺
肿瘤转移
因素分析
统计学
危险因素
carcinoma, non-small cell lung
neoplasm metastasis
factor analysis, statistial
risk factors
