摘要
目的探讨甲状旁腺功能减退症（HP）伴肌酶改变的临床资料及与年龄、性别、病程、血清总钙、总磷、甲状旁腺激素（eri-i）的关系。方法对2005年1月至2011年10月郑州大学第一附属医院内分泌科收治的HP患者41例病历资料进行回顾性分析。结果41例HP中16例伴肌酶增高，25例肌酶正常。16例肌酶增高患者中特发性HP（IHP）11例，假性HP（PHP）5例；血钙（1．53±0．25）mmol／L，血磷（2.1±0．6）mmol／L，血清肌酸激酶（CK）、乳酸脱氢酶（LDH）、天冬氨酸转氨酶（AST）分别为309（126～10046）U／L、279（131—741）U／L、27（17—467）U／L。25例肌酶正常患者中IHP20例，PHP5例；血钙（1．64±0．29）mmol／L，血磷（2．2±0．6）mmo]／L；CK（124±45）U／L，LDH（189±22）U／L，AST（25．6士7．3）U／L。16例HP肌酶增高患者治疗前后肌酶进行比较，肌酶水平均随血钙浓度的升高明显降低。HP患者的CK（r=-0．82）、LDH（r=-0．55）、AST（r=-0．56）的增高与血钙浓度呈负相关（均P〈0．05）；与年龄、性别、病程、血清磷、PTH均无相关性（P〉0．05）。结论HP患者的肌酶增高与血清钙呈负相关，与年龄、性别、病程、血清磷、PTH均无相关性；且各种酶学的变化随着血钙水平的正常而逐渐恢复。
Objective To examine the clinical features of hypoparathyroidism （HP） with altered serum muscle enzymes and explore the correlations with age, gender, disease duration, serum total calcium, serum total phosphorus and parathyroid hormone （PTH）. Methods From January 2005 to October 2011, a total of 41 HP patients at our hospital were retrospectively analyzed. Results There were 16 patients with elevated serum muscle enzymes and 25 with normal serum muscle enzymes. The former group included 11 patients of idiopathic hypoparathyroidism （IHP） and 5 of pseudohypoparathyroidism （PHP） ; serum calcium was （ 1.53 ±0.25） mmol/L and serum phosphorus （2.1 ± 0.6） mmol/L; medians of creatine kinase （ CK）, lactic dehydrogenase （LDH）, aspartate amino transfer enzymes （AST） were 309（ 126 -10 046）, 279（ 131 - 741 ）and 27 （ 17 -467）U/L in HP patients respectively. And the latter group included 20 IHP patients and 5 PHP ones; serum calcium was （ 1.64 ± 0.29） mmol/L and serum phosphorus （2.2 ± 0.6） mmol/L. The levels of serum muscle enzyme were compared before and after treatment in the former group. And they significantly declined with the rising serum level of calcium after treatment. The serum levels of CK （ r = -0. 82）, LDH（r = -0.55）and AST（r = -0.56）in HP patients with elevated serum muscle enzymes had a negative correlation with the serum level of calcium （ all P 〈 0.05 ）. And there was no correlation with age, gender, disease duration or serum total phosphorus （P 〉 0.05）. Conclusion Elevated serum muscle enzymes in HP patients have a negative correlation with serum level of calcium and there is no correlation with age, gender, disease duration, serum total phosphorus or parathyroid hormone. And elevated serum muscle enzymes are gradually restored with the normalized serum level of calcium.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2013年第2期135-137,共3页
National Medical Journal of China
关键词
甲状旁腺功能减退症
肌酸激酶
钙
肌酶
Hypoparathyroidism
Creatine kinase
Calcium
Muscle enzyme
