摘要
将125只大鼠分成5组,分别给予如下处理;①半胱胺,②半胱胺+异搏定,③半胱胺+钙,④钙,⑤对照。在解剖显微镜下评价十二指肠溃疡(DU)发生率和程度,用原子吸收光谱分析法测定钙含量。给果表明:①半胱胺诱发DU的大鼠其十二指肠粘膜钙含量高于对照组,但胃粘膜钙含量和血清钙无变化;③钙阻通剂异搏定能降低半胱胺所致的DU发生率及严重程度并伴有十二指肠粘膜钙含量降低;③钙能增加半胱胺所致DU发生率及严重程度并使十二指肠粘膜钙含量增加;④十二指粘膜钙含量与DU严重程度显著相关。提示十二指肠粘膜钙的聚集在大鼠DU发生中可能起重要作用。
One hundred and twenty five rats were divided into five groups, each of which received different treatment as follow: ①cysteamine, ②cysteamine plus verapamil, ③cysteamine plus calcium, ④calcium, ⑤control. The frequency and severity of DU were evaluated by using a dissecting microscope;and the content of calcium was measured by atomic absorption spectroscope (AAS). Our results showed that s ①rats with DU induced by cysteamine had higher calcium content of duodenal mucosa than control rats but not changeable in calcium content of gastric mucosa and serum calcium; ②calcium blockade with verapamil could reduce the frequency and severity of DU induced by cysteamine, accompanied with decrease in calcium content of duodenal mucosa; ③calcium could strengthen the frequency and severity of DU induced by cysteamine, accompanied with increase in calcium content of duodenal mucosa; ④a significant positive correlation between calcium content of duodenal mucosa and the severity of DU. We conclude that calcium cumulation in duodenal mucosa may play an important role in duodenal ulceration of rats.
出处
《中山医科大学学报》
CSCD
1991年第3期188-192,共5页
Academic Journal of Sun Yat-sen University of Medical Sciences
关键词
十二指肠溃疡
十二指肠粘膜
钙
Duodenal ulcer Calcium content of duodenal mucosa Calcium content of gastric mucosa Serum calcium Rat
