摘要
目的:探讨不同部位封堵左前降支(left anterior descending artery,LAD)对猪急性心肌梗死(acute myocardial infarction,AMI)模型恶性心律失常发生情况及其与QT间期、校正后QT间期(QTc间期)的关系。方法:选择22头苏中幼猪,采用介入法球囊封堵猪LAD建立AMI动物模型。根据LAD封堵造模的部位,将动物随机分为3组,其中假手术对照组(Sham组,不封堵)4只,LAD下1/3处封堵组和LAD中部封堵组各9只,观察各组在造模过程中恶性心律失常(室性心动过速或心室颤动)的发生率,造模成功后记录并分析各组心电参数指标。结果:LAD中部封堵组心室颤动发生率显著高于下1/3处封堵组(100.00%vs33.33%,P<0.05)。造模成功后,LAD中部封堵组QT间期同下LAD 1/3处封堵组比较,差异无统计学意义[(362.11±29.18)ms vs(338.78±22.65)ms,P>0.05];而LAD中部封堵组QTc间期较下LAD 1/3处封堵组延长,差异具有统计学意义[(462.67±27.55)ms vs(425.56±21.96)ms,P<0.01]。结论:猪急性心肌梗死后恶性心律失常发生与QTc间期延长具有一定的相关性。
Objective：To explore the malignant arrhythmia of swine models in plugging left anterior descending artery （LAD） at different segments and its association with QT and QTc interval. Methods：Total 22 swine were chosen to undergo occlusion of coronary artery with balloon angioplasty. The animals were randomly divided into 3 groups according to the occlusion position of balloon：①Sham group：no occlusion of LAD（n = 4）;② The occlusion at lower 1/3 segment of LAD group（n = 9）; ③ The occlusion at middle segment of LAD group （n = 9）. Then the incidence of malignant arrhythmia （ventricular tachycardia or ventricular fibrillation） was observed in the process of molding,and the QT and QTc interval were analyzed after models made successfully. Results： The incidence of ventricular fibrillation in the middle segment of LAD plugging group was significantly higher than the lower 1/3 segment of LAD plugging group （100% vs 33.33% ,P 〈 0.05）. After the models constructed,the QT interval between the two groups showed no significant difference [（362.11±29.18） ms vs （338.78 ± 22.65） ms,P 〉 0.05]. However,the QTc interval was significantly longer in the middle segment of LAD plugging group than in the lower 1/3 segment of LAD plugging group[ （462.67 ± 27.55） ms vs （425.56 ± 21.96）ms,P 〈 0.01）. Conclusion：Malignant arrhythmia after acute myocardial infarction in swine models was associated with prolonged QTc interval.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2012年第11期1533-1536,共4页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏高校优势学科建设工程项目(Jx10231081)
关键词
急性心肌梗死
猪模型
恶性心律失常
QTC间期
acute myocardial infarction
swine model
malignant arrhythmia
QTc interval
