摘要
目的:探讨老年帕金森病(PD)患者血尿酸水平的改变及其与抑郁、认知功能障碍的关系。方法:对老年PD患者(PD组)和健康老年人(对照组)各55例进行血尿酸水平检测;采用汉密尔顿抑郁(HAMD)量表和简易精神状态检查(MMSE)量表对PD组评定。结果:PD组血尿酸水平较对照组显著降低(P<0.05),且PD组中伴抑郁、认知功能障碍患者的血尿酸水平均显著低于PD无抑郁、无认知功能障碍患者(均P<0.05)。PD组中伴抑郁患者的MMSE量表评分显著低于PD无抑郁患者(P<0.05)。结论:老年PD患者血尿酸水平有明显的降低,其水平变化与抑郁、认知功能障碍的发生相一致。
Ohjective： To investigate the change of serum uric acid level and its relationship with depression and cognitive dysfunction in old patients with Parkinson disease（PD）. Methods： Serum uric acid was measured in 55 elderly PD patients （PD group）and 55 healthy elderly people （control group）. Elderly PD patients were measured by Hamilton depression rating scale（HAMD） and Mini-mental state examination scale（MMSE）. Results：The level of serum uric acid of PD group was significantly lower than that of control group（P〈0.05） ,and the level of serum uric acid of PD patients with depression or cognitive dysfunction was significantly lower than that in PD patients without depression or cognitive dysfunction （all P〈0. 05）. The MMSE score in PD group with depression was significantly lower than that in PD patients without depression（P〈0. 05）. Conclusions：The level of serum uric acid in elderly PD patients is decreased significantly,which even lower in elderly PD patients with depression or cognitive dysfunction.
出处
《中国康复》
2012年第4期271-273,共3页
Chinese Journal of Rehabilitation
关键词
老年帕金森病
尿酸
抑郁
认知
elderly Parkinson disease
uric acid
depression
cognitive
