摘要
目前,大多数作者都认为癌胚抗原(CEA)是一种对消化系癌肿有较强特异性的抗原。本文应用抗CEA抗体对早期胃癌、中晚期胃癌以及各种癌前期病变进行标记。
The antibody to carcinoembryonic antigen (CEA) is used to label the tissue speci-mens of gastric cancer and precancerous conditions with ABC method and observed bylight and electronic microscope. CEA usually show negative in normal gastric mucosaand positive in embryonic gastric mucosa. The positive rate is 68.6% in intestinalmetaplasia, 66.7% in gastric adenoma, 35.3% in dysplasia related with the degree ofdysplasia, 53.9% in the severe degree. The positive rates are 76.3% and 85.7% inearly and advanced gastric cancer respectively. In respect of histologic type, thepositive rates in signet ring cell carcinoma (93.3%) and papillary carcinoma (91.7%)are higher than that in other types. The ultrastructural localization of CEA is mainlygathered at membrane microvilli, rough endoplasmic reticulum, mucous granule, butthe nucleus and mitochondria show negative.
出处
《肿瘤》
CAS
CSCD
北大核心
1990年第2期57-59,共3页
Tumor
基金
国家自然科学基金(84)会生准字125号资助课题
