摘要
目的探讨内皮素(endothelin,ET)及血小板聚集率在妊娠期高血压疾病中的作用及关系。方法用放射免疫法及血凝测试仪同时抽血测定55例正常妊娠组及55例妊娠期高血压疾病组血浆中的ET及血小板聚集率。结果妊娠期高血压疾病组较正常妊娠组ET升高(P<0.01),血小板聚集率增高(P<0.05);妊娠期高血压疾病组间比较随着妊娠期高血压疾病的加重,ET及血小板聚集率呈逐渐增高趋势(P<0.05);直线相关分析表明:随着妊娠期高血压疾病的加重,ET与血小板聚集率的关系越密切,呈正相关(r1=0.478,P<0.05;r2=0.612,P<0.01;r3=0.732,P<0.01)。结论妊娠期高血压疾病患者存在着内皮细胞功能紊乱,内皮素增加血小板聚集率增高,且二者与妊娠期高血压疾病的程度密切相关。内皮素与血小板可能参与了妊娠期高血压疾病的发生发展,因此测定内皮素与血小板聚集率有助于妊娠期高血压疾病的诊断和治疗。
Objective To probe into the role and the relationship of ET and the Blood Platelet Aggregate Rate in plasma in the development of hypertensive disorders in pregnancy. Methods The level of ET and BPAR in plasma were measured with radio-immunity and a blood coagulation test instrument in 55 cases of normal group and 55 cases of hypertensive disorders in pregnancy group. Results Compared with the pregnant group,ET and BPAR increased respectively （P〈0.01 ,P〈0.05）in the hypertensive disorders in pregnancy group.Compared within the hypertensive disorders in pregnancy group,ET and BPAR showed an increasing trend as long as the hypertensive disorders in pregnancy was getting worse （P〈0.05）. Linear correlation analyse showed that the worse the hypertensive disorders in pregnancy was, the closer relationship of ET and BPAR was （r1=0.478, P〈0.05 ;r2=0.612, P〈0.01 ;r3=0.732, P〈0.01 ）. Conclusion Patients with hypertensive disorders in pregnancy suffered from functional disorder of endothelium cell, an increasing of ET and BPAR and also,they had a close correlation with the degree of the hypertensive disorders in pregnancy. ET and BPAR may have taken part in the formation and development of the hypertensive disorders in pregnancy. Therefore, measurement of ET and BPAR will be helpful in the diagnosis and treatment of the hypertensive disorders in pregnancy.
出处
《基层医学论坛》
2012年第22期2874-2875,共2页
The Medical Forum
关键词
妊娠
高血压
内皮素
血小板聚集率
Pregnancy Hypertensive Endothelin Platelet aggregation rate
