摘要
目的探讨粪便Hp抗原(HpSA)及14 C-尿素呼气试验(14 C-UBT)2种非侵入性检测方法对幽门螺杆菌(Hp)感染的诊断价值。方法采用胃黏膜快速尿素酶法(RUT)和活组织切片染色法联合检测的结果作为Hp感染诊断的"金标准",对2009年1月-2011年6月在新疆医科大学附属中医医院门诊就诊的因上消化道症状接受胃镜检查的132例患者进行粪便Hp抗原(HpSA)及14 C-尿素呼气试验(14 C-UBT)的检测,并与"金标准"进行对比分析。结果 132例患者中RUT法检出Hp阳性95例,组织切片染色法检出Hp阳性92例,其中81例2种方法检测均阳性,将此81例患者作为Hp感染的现症患者,26例2种方法均阴性者作为Hp非感染者。对"金标准"检测的81例Hp阳性患者及26例阴性患者再行HpSA及14 C-UBT检测。以"金标准"作为Hp感染的诊断标准,14 C-UBT检测的敏感性为95.06%(77/81),特异性为92.31%(24/26),阳性预测值为97.47%(77/79),阴性预测值为85.71%(24/28),准确性为94.40%(101/107);HpSA检测的敏感性为91.36%(74/81),特异性为88.46%(23/26),阳性预测值为96.10%(74/77),阴性预测值为76.67%(23/30),准确性为90.65%(97/107)。结论 HpSA及14 C-UBT检测是非侵入性诊断Hp感染的较理想的方法,值得在临床推广,临床医生可根据具体情况选择检测方法,也可以联合运用检测方法来减少假阴性或假阳性结果的出现。
Objective To study the values of Helicobacter pylori stool antigen （HpSA） test and^14C- breath test （14C-UBT） in the diagnosis of Helicobacter pylori （Hp） infection in patients. Methods tric mucosal results as ＇g rap old -urea Gas- id urease enzyme （RUT） and staining method combined with Hp infection diagnostic test standard＇, 132 cases from January 2009- J une 2011 were taken endoscopy because of symptoms of upper gastrointestinal. The 14C-UBT and HpSA test were undertaken, and the results were compared with the ＇gold standard＇. Results In 132 patients, 92 cases were detedcted as Hp positive, the RUT method detected 95 cases as Hp positive, of which 81 cases were detected positive for two methods. 26 cases were negative by the two methods as Hp non-infected group. These 81 patients with Hp positive patients and 26 cases of patients were taken with 14 C-UBT and HpSA test. The sensitivity of 14 C-UBT test was95.06% （77/81）, the specificity was 92.31% （24/26）, the positive predictive value was 97.47% （77/79）, the negative predictive value was 85.71% （24/28）, the accuracy was 94.40% （101/107） ; The sensitivity of HpSA detection was 91.36% （74/81）, the specificity was 88.46% （23/26）, the positive predictive val- ue 96.10% （74/77）, the negative predictive value was 76.67% （23/30） and the accuracy was 90.65% （97/107）. Conclusion The HpSA test can be used as an reliable non-invasive diagnostic methods for Heli- cobacter pylori in children. Other detection methods can be combined to reduce the use of false negative or false positive results occur.
出处
《新疆医科大学学报》
CAS
2012年第7期949-952,共4页
Journal of Xinjiang Medical University
基金
新疆医科大学科研创新基金项目(ZYY201008)
