摘要
本文应用紫外分光光度法对8名老年慢性阻塞性肺病(Chronic ObstructivePulmonary Disease,COPD)伴有肺心病、肺气肿患者单剂量口服氨茶碱(Aminophylline,AP)200mg 后的药物动力学进行了研究。结果表明:患者单剂量口服AP 后体内药物处置呈一室模型,消除半衰期在7.819～21.53h 之间,平均值为14.23±5.206h,比文献记载的正常人单剂量口服AP 的半衰期增加大约5.5h。
Study On the Pharmacokinetics of Single 2(?) mg Oral dose of Aminophyllinein 8 elderly Chronic obstructive pulmonary disease(COPD)Patients With Pneu-monectasis and Chronic Pulmonary Cardiopathic Was made using UV-spectropho-tometry.The results Showed that the drug disposition revealed one Compartmentmodel Elimination half-Life Was 7.819～21.53h.Mean value was 14.23±5.206h,which was 5.5h more than that reported on other references for normal humant.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1990年第10期435-437,共3页
Chinese Journal of Hospital Pharmacy
关键词
COPD
氨茶碱
药物动力学
老年人
Elderly human
Chronic obstructive pulmonary sisease
Aminophylline
