摘要
目的 探讨组织蛋白酶D(CD)、表皮生长因子受体 (EGFR)的表达与膀胱移行细胞癌(BTCC)生物学行为间的关系及其发生浸润转移的机制。方法 应用免疫组化ABC法检测 33例BTCC及 12例正常膀胱组织中CD、EGFR的表达。结果 正常膀胱移行细胞CD均呈弱阳性表达 ,BTCC组肿瘤细胞CD中 /强阳性表达率显著高于正常对照组 (P <0 0 5 ) ,且在不同病理分级 ,临床分期 ,单发与多发 ,初发与复发组间均有显著性差异 (P <0 0 5 )。BTCC组CD、EGFR的过表达率有显著相关性 (P <0 0 5 )。结论 CD与BTCC生物学特性密切相关 ,与EGFR协同作用促进肿瘤发生浸润转移。
Objective To evaluate the relationship between the expression of cathepsin D(CD)or epidermal growth factor receptor (EGFR)and biological behavior of bladder transitional cell carcinoma(BTCC)and the mechanisms of invasiveness and metastasis.Methods The expression of CD and EGFR was detected by standard ABC immunohistochemical technique in 33 paraffin embedded tissue specimens of BTCC.Results CD antigen was weakly stained in all normal transitional cells.The moderately or strongly positive rate of CD in BTCC group was significantly higher than that in normal control group(P<0 05).Fisher’s accuracy analysis showed that moderately and strongly positive rate of CD in tumor cells were closely correlated with different pathological grades(P<0 05),clinical stages(P<0 05),number of lesions(P<0 05)and postoperative recurrence(P<0 05).The over expression of CD and EGFR showed significant relativity in the same groups of BTCC(P<0 05).Conclusion The over expression of CD was closely correlated with complex and variable biological characteristics of BTCC.The synergy of CD and EGFR may influence the invasiveness and metastasis of BTCC.
出处
《江苏医药》
CAS
CSCD
2000年第6期432-432,434,共2页
Jiangsu Medical Journal
关键词
膀胱肿瘤
组织蛋白酶D
移行细胞癌
EGFR
Bladder neoplasms Carcinoma Cathepsin D Epidermal growth factor receptor
