摘要
目的 探讨进展期胃癌根治术后腹腔温热化疗的临床疗效价值。方法 将本组 167例行根治性切除进展期胃癌病人随机分成治疗组和对照组。 2组病人性别、年龄、癌变部位、TNM分期差异无显著性。治疗组 86例应用卡铂 2 0 0mg、氟脲嘧啶 75 0～ 10 0 0mg、利多卡因 40 0mg、地塞米松 3 0mg分别溶入 15 0 0ml温热生理盐水 ( 4 5℃ )行左、右下腹部穿刺灌注 ,每周 1次 ,连用 5周 ,半年后重复。对照组 81例给予复方氟脲嘧啶多相质液口服。结果 治疗组和对照组 3年生存率分别为 62 .8%、44.4% ,腹腔转移率分别为 7.4%、3 6.1% ,两组统计差异非常显著 (P <0 .0 1)。结论 进展期胃癌根治术后行腹腔温热化疗临床疗效确切 ,是一种操作简便、安全、经济。
Objective To study the effect of intraperitoneal warm chemotherapy for the advanced gastric carcioma after radical resection.Methods 167 patients with advanced gastric carcinoma,having received radical resection,were divided randomly into two groups,the treated group and the control group.The two groups had no significant difference on sex,age,tumor location,TNM stage.The solution of carbopltain 200 mg,5 Fluorouracil 750 1 000 mg,lidocaine 400 mg,dexamethasone 30 mg in 1 500 ml warm saline(45℃) was injected at left and right abdomen using enterocelia perfusion for the treated group(86 patients),once a week for five weeks,and this was repeated after half a year.The control group(81 patients )received fluorouracil polyphase liposome perorally. Results The 3 year survival rate of the treated and the control group was 62.8%,44.4% respectively,the enterocelia metastasis rate was 7.4% ,36.1%respectively.There was a significant statistic difference between the two groups(P<0.01).Conclusion Using intraperitoneal warm chemotherapy for the advanced gastric carcinoma after radical resection is effective,easy,safe,economic and has less by effect.
出处
《河北医药》
CAS
2000年第4期266-267,共2页
Hebei Medical Journal
关键词
胃肿瘤
腹腔
温热化疗
gastric carcinoma
warm chemotherapy
enterocelia perfusion
