摘要
髓系抑制性细胞（myeloid—derived suppressor cells，MDSC）是髓系来源的一群异质细胞，具有强大的免疫抑制功能。在病理情况下可大量扩增，包括各种感染、肿瘤和急慢性炎症等。在肿瘤模型和肿瘤患者体内均发现有MDSC，其促进肿瘤免疫逃避的机制已取得很大进展。寄生虫感染一般都伴随免疫逃避和显著抑制机体免疫应答的现象，而目前较少关注MDSC在寄生虫感染中的免疫抑制功能。该文综述了一些种类的原虫和蠕虫感染中，MDSC的扩增、活化、趋化、表型和功能。
Myeloid-derived suppressor cells （MDSC）are a heterogeneous population of immature myeloid cells with potent immunosuppressive function which have been proved to expand under various pathological conditions,including a lot of infections, cancers, acute and chronic inflammations. MDSC play an important role in tumour-bearing mice and cancer patients by enhancing immune escape. Parasitic infections are accompanied by immune escape and notoriously associated with suppression of immune responses, during which the role of MDSC is paid little attention to. In this review, we discussed the mechanisms of MDSC expansion, activation, recruitment, phenotype and functions during parasitic infection including several helminth and protozoan species.
出处
《国际医学寄生虫病杂志》
CAS
2012年第2期105-110,共6页
International JOurnal of Medical Parasitic Diseases
基金
国家重点基础研究发展规划项目资助（973计划）（2010CB530004）
关键词
髓系抑制性细胞
寄生虫感染
免疫抑制
Myeloid-derived suppressor cells
Parasitic infection
Immunosuppression
