摘要
[目的]探讨当前主要的DNA序列映射方法对蛋白质编码区的预测准确率的影响,寻找有效的映射方法。[方法]以AC(Approxi-mate Correlation)为碱基层的预测准确率的测度,采用FIR(Finite Impulse Response)窄通带滤波器预测算法研究各种映射方法对预测准确率的影响。[结果]在ALLSEQ和HMR195 2个DNA序列集上,Voss法和Z-curve方法是较PN(Paired Numeric)法、EIIP(Electron-IoInteraction Potential)法和复数法更为有效的映射方法。[结论]该研究结果为用预测结果的AC值来验证新映射方法的有效性奠定了基础,对利用生物信息学方法正确揭示DNA序列的结构具有重要意义。
[Objective]To discuss the effects of major mapping methods for DNA sequence on the accuracy of protein coding regions prediction,and to find out the effective mapping methods.[Method] By taking Approximate Correlation（AC） as the full measure of the prediction accuracy at nucleotide level,the windowed narrow pass-band filter（WNPBF） based prediction algorithm was applied to study the effects of different mapping methods on prediction accuracy.[Result] In DNA data sets ALLSEQ and HMR195,the Voss and Z-Curve methods are proved to be more effective mapping methods than paired numeric（PN）,Electron-ion Interaction Potential（EIIP） and complex number methods.[Conclusion] This study lays the foundation to verify the effectiveness of new mapping methods by using the predicted AC value,and it is meaningful to reveal DNA structure by using bioinformatics methods.
出处
《安徽农业科学》
CAS
2012年第6期3234-3238,共5页
Journal of Anhui Agricultural Sciences
基金
宁夏自然科学基金(NZ1024)
宁夏高校科学研究项目(201027)资助
关键词
预测准确率
蛋白质编码区
映射方法
加窗
窄通带滤波器
Prediction accuracy
Protein coding regions
Mapping method
Windowed
Narrow pass-band filter
