摘要
目的：研究高压氧暴露对红细胞、淋巴细胞免疫功能的影响及可能机制。方法：小鼠暴露于0．25MPa（2．5ATA）99．2％O2的高压氧下2小时，测定红细胞、淋巴细胞的免疫粘附功能及血浆丙二醛（MDA）含量，血浆β-内啡肽（β-EP）浓度。结果：HBO暴露下红细胞、淋巴细胞免疫粘附功能均下降，同时血浆MDA，β－EP含量升高。结论：HBO暴露可抑制机体免疫功能，这种抑制作用可能与脂质过氧化损伤及神经内分泌调节有关。
Aim: To study the effects of hyperbaric oxygen(HBO)on the immune functions of red blood cells(RBC) and lymphocytes and its possible mechanisms. Methods: Mice were exposed to 99. 2 % oxygen at 0. 25Mpa for two hours, and the immune adherence function of RBC, lymphocyte,plasma malondial dehyde(MDA) and β-endorphin (β-EP) contents were determined. Reslt: The immune functions of RBC and lymphocyte were significantly suppressed, meanwhile, plasma MDA and β-EP contents wee markly increased during the expeure to HBO. Chnclusion: the body immune function could be suppressed by HBO exposure,which is possibly related with oxidative injuries and the stress of the body.
出处
《海南医学》
CAS
2000年第1期21-22,共2页
Hainan Medical Journal
关键词
高压氧
红细胞
淋巴细胞
免疫功能
Hyperbaric oxygen
Erythrocyte
Lymphocytes
Immunity
