摘要
目的通过正交试验确立冠舒滴丸的最佳成型工艺。方法通过预试验确定选用基质、药材提取物与基质配比及冷却剂,以滴丸成型率(%)为筛选指标,以滴丸滴制温度、滴制过程的滴速和冷凝柱长度为考察因素,采用正交试验法优选冠舒滴丸的最佳制备工艺。结果滴制温度为85℃、滴速为60～70滴/min、冷凝柱长度为80 cm,制备滴丸成型率最高。结论该工艺稳定可靠,制备的滴丸成型率高,各项指标符合《中国药典》(2010版)滴丸质量标准。
Objective To establish an optimized preparation procedure for Guanshu Drop Pills. Methods The matrix, the ratio of the extract to the matrix and the refrigerant were established by preliminary experiments. With molding probability of drop pills as the evaluation quota, the best preparation was determined. The dropping rate of drop pills and the height of the freeze- pillar were studied with L9 （34 ） orthogonal design. Results The tem- perature of the drug was 85~C. The dropping rate was 60-70 droppings per minute,and the freeze-pillar height was 80 cm. Moulding probability was high. Conclusion This method is stable and reliable. All the indexes of the experiment conform to Chinese Pharmacopoeia（2010）.
出处
《解放军药学学报》
CAS
2011年第6期490-492,共3页
Pharmaceutical Journal of Chinese People's Liberation Army
关键词
冠舒滴丸
成型工艺
正交试验
guanshu Drop Pills
moulding technique
qrthogonal design
