摘要
目的:探讨乙型肝炎患者HBsAg和抗HBs共存模式及与HBV DNA的关系。方法:采用增强化学发光法检测血清乙肝标志物,并采用荧光定量PCR法检测HBV DNA。结果:5717例慢性乙肝患者检测出HBsAg和抗HBs双阳性248例,占4.34%,其中多数与HBV DNA同时出现。结论:HBsAg和抗HBs同时阳性并不少见,慢性乙肝患者出现抗HBs,不完全代表病毒复制终止,需结合HBV DNA定量综合分析。
Objective：To study the relationship between concurrence mode of hepatitis B surface antigen and anti-HBs antibodies in patients with chronic hepatitis B virus infection and HBV DNA.Methods：Serological diagnosis for HBV infection was detected by VITROS ECi/ECiQ immunodiagnostic systems and HBV DNA viral load was quantified by using the commercially available real-time fluorescence quantitative kit（PG Biotech）.Results：Among the 5717 patients monitored at our hospital,248（4.34%） have been identified as carrying both HBsAg and anti-HBs antibodies.In which,the majority appeared with HBV DNA at the same time.Conclusion： Coexistence of HBsAg and anti-HBs is not rare.HBV DNA concentration is an important parameter to diagnose and treat patients with simultaneous positive for HBsAg and anti-HBs antibodies.
出处
《中国卫生检验杂志》
CAS
2011年第11期2616-2617,共2页
Chinese Journal of Health Laboratory Technology
