摘要
7-ACA和MAEM在三乙胺和吡啶的催化作用下缩合得到头孢噻肟酸,头孢噻肟酸在六甲基二硅烷和碘条件下与2,3-环戊烯并吡啶发生取代反应,得到头孢匹罗二氢碘酸盐,再经过新型离子交换树脂进行转盐反应,获得最终产品硫酸头孢匹罗,总收率为63%(以7-ACA计).目标化合物结构经核磁共振氢谱及质谱确证.
Cefotaxime,which was prepared from 7-ACA and MAEM in triethylamine and pyridine,was subsequently reacted with 2,3-cyclopenopyridine in the presence of hexamethyldisilazane and iodine to give cefpirome dihydroiodide.It was further treated that new ion exchange resin was afforded the target compound cefpirome sulfate in 63 % overall yield（based on 7-ACA）.Structure of the target compound was confirmed by 1H-NMR and MS.
出处
《沈阳化工大学学报》
CAS
2011年第3期225-228,共4页
Journal of Shenyang University of Chemical Technology
关键词
头孢匹罗
抗生素
合成
改进
cefpirome
antibiotics
synthesis
improvement
