摘要
目的探讨抗抑郁治疗在幽门螺旋杆菌阴性的慢性胃炎治疗方案中的作用。方法将160例幽门螺旋杆菌阴性的慢性胃炎患者随机分成联合治疗组和常规治疗组(对照组),常规治疗组80例予以奥美拉唑胶囊治疗,联合治疗组80例予以奥美拉唑胶囊及抗抑郁药物(帕罗西汀)联合治疗4周,比较2组治疗前后的疗效。结果联合治疗组后患者的症状改善程度明显优于常规治疗组,生活质量改善,差异有显著性。结论在常规治疗基础上联合抗抑郁药物治疗,对幽门螺旋杆菌阴性的慢性胃炎疗效显著,明显提高生活质量,具有推广意义。
Objective To explore the role of antidepressant therapy in H.pylori negative chronic gastritis and treatment programs.Methods One hundred and sixty patients with H.pylori negative chronic gastritis were randomly divided into combined treatment group and the conventional treatment group（control group）.Conventional treatment group（n=80） was treated with Omeprazole capsules,while the combined treatment group（n=80） was treated with Omeprazole capsules and antidepressant medication（paroxetine） for 4 weeks.The efficacy of the two groups before and after treatment were compared.Results The improved symptoms of the combined treatment group were significantly superior to the conventional treatment group.The quality of life was improved and the difference was significant.Conclusion On the basis of conventional therapy combined antidepressant treatment can better treat H.pylori negative chronic gastritis.It can improve quality of life and deserve wider clinical application.
出处
《实用临床医药杂志》
CAS
2011年第11期109-110,115,共3页
Journal of Clinical Medicine in Practice
关键词
抗抑郁治疗
幽门螺旋杆菌
慢性胃炎
antidepressant treatment
Helicobacter pylori
chronic gastritis
