摘要
目的探讨血液透析患者血清软骨寡聚基质蛋白(cartilage oligomeric matrix protein,COMP)浓度与血管钙化及心血管事件的关系。方法比较血液透析患者与正常对照组血清COMP浓度的差异,且根据患者血清COMP水平,将北京大学第三医院血液净化中心54例维持性血液透析患者分成高、低浓度2组,胸片法评估2组间基线血管钙化情况,并随访20个月,观察2组间心血管事件的发生情况。结果低浓度组和高浓度组的基线血管钙化发生率分别是64.5%(20/31)和91.3%(21/23),差异有统计学意义(?2=5.184,P=0.023),相应的随访过程中心血管事件的发生率分别是10.4%(3/29)和40.9%(9/22),差异有统计学意义(?2=6.495,P=0.011)。回归分析提示高浓度血清COMP是维持性血液透析患者发生严重心血管事件的预测因素之一。结论血液透析患者血清COMP浓度可能是血管钙化及心血管事件的危险因素。
Objective To investigate the correlation of plasma cartilage oligomeric matrix protein（COMP） with vascular calcification and cardiovascular events in hemodialysis patients.Methods Plasma COMP levels in hemodialysis patients and normal controls were determined and analyzed.Fifty-four hemodialysis patients were divided into two groups based on plasma COMP level,and they were followed up for 20 months.Vascular calcification of thoracic aorta was evaluated by chest X-ray examination at the beginning.Cardiovascular events were analyzed at the end of the follow-up period.Results At the beginning of the follow-up period,vascular calcification was detected in 20/31 and 21/23 patients in the low COMP group and the high COMP group,respectively（64.5% vs.91.3%,P = 0.023）.During the follow-up period,cardiovascular events were found in 3/29 and 9/22 patients in the low COMP group and the high COMP group,respectively（10.4% vs.40.9%,p=0.011）.Regression analysis showed that higher plasma COMP level was one of risk factors for cardiovascular events in maintenance hemodialysis patients.Conclusion Elevated plasma COMP level may be a risk factor for vascular calcification and cardiovascular events in hemodialysis patients.
出处
《中国血液净化》
2011年第5期254-257,共4页
Chinese Journal of Blood Purification
关键词
血液透析
血清软骨寡聚基质蛋白
血管钙化
心血管事件
Hemodialysis
Cartilage oligomeric matrix protein
Vascular calcification
Cardiovascular events
