摘要
目的观察龙草颗粒对高血压大鼠血管ET和NO表达的影响。方法将高血压大鼠(SHR)分为阳性对照组、龙草颗粒大剂量组、龙草颗粒小剂量组、阴性对照组和Wistar大鼠组。连续灌胃1个月。采用免疫组织化疗S-P法和原位杂交方法检测血管ET和NO表达。结果龙草颗粒可使高血压大鼠血管ET下调,高血压大鼠血浆NO表达上调。结论龙草颗粒可通过调节血管ET及NO表达水平,改善内皮功能而发挥其降压作用。
Objective To observe the effects of Long Cao Particles on the expression of ET and NO in hypertensive rats＇ vessels.Methods Divide the spontaneously hypertensive rats（SHR） into such groups as positive,large dose of Long Cao Particles,small dose of Long Cao Particles,negative and wistar.After a month of intragastric administration,test the expression of ET and NO in the vessels by means of immune tissue S-P chemotherapy and hybridization in situ.Results Long Cao Particles can reduce ET and raise the expression of NO in hypertensive rats＇ vessels.Conclusion By regulating the expression of ET and NO level in vessels,Long Cao Particles can improve the endothelial function and bring high blood pressure down.
出处
《中国药物警戒》
2011年第5期260-262,共3页
Chinese Journal of Pharmacovigilance
基金
济南科学技术局立项课题(济科合字2006061046-1)
