摘要
目的:探讨硝酸甘油雾化吸入对新生儿呼吸衰竭的治疗作用。方法:将110例呼吸衰竭的新生儿分为硝酸甘油组和对照组各55例。硝酸甘油组给予雾化吸入硝酸甘油20μg/(kg.次),4次/d,连用3天;对照组给予雾化吸入等容量生理盐水4次/d,连用3天。在治疗前后测定血内皮素-1(ET-1)。观察记录TcSO2达93%的时间,CPAP时间和住院时间。结果:治疗前两组ET-1、TcSO2水平差异无统计学意义;治疗后硝酸甘油组PaO2、PaCO2等明显改善(P<0.05);ET-1显著降低(t=3.65,P<0.01)。硝酸甘油组TcSO2达93%的时间及使用CPAP和住院时间均比对照组明显缩短(P<0.01)。结论:硝酸甘油雾化吸入治疗新生儿呼吸衰竭具有较好的临床疗效。
Objective：To explore the therapeutic effect of aerosol inhalation of nitroglycerin on neonates with respiratory failure. Methods：110 neonates with respiratory failure were divided into nitroglycerin group and control group,55 neonates in each group;the neonates in nitroglycerin group were treated with aerosol inhalation of nitroglycerin,20 μg/kg once,4 times per day for 3 days;the neonates in control group were treated with aerosol inhalation of normal saline of equivalent volume,4 times per day for 3 days.The levels of endothelin-1（ET-1） in blood were detected before and after treatment;the time of TcSO2 reaching 93%,CPAP time and hospitalization time were observed and recorded. Results：Before treatment,there was no significant difference in ET-1 and TcSO2 levels between the two groups.After treatment,PaO2 and PaCO2 levels in nitroglycerin group were improved significantly（P〈0.05）;the level of ET-1 decreased significantly（t=3.65,P〈0.01）;the time of TcSO2 reaching 93%,CPAP time and hospitalization time in nitroglycerin group were significantly shorter than those in control group（P〈0.01）. Conclusion：The clinical efficacy of aerosol inhalation of nitroglycerin in treatment of neonates with respiratory failure is good.
出处
《中国妇幼保健》
CAS
北大核心
2011年第9期1331-1332,共2页
Maternal and Child Health Care of China
基金
四川省卫生厅科研课题(060041)
关键词
硝酸甘油
雾化吸入
新生儿
呼吸衰竭
内皮素-1
Nitroglycerin； Aerosol inhalation； Neonates； Respiratory failure； Endothelin-1
