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创伤性脑损伤后大鼠海马区糖皮质激素受体mRNA的表达 被引量：2

Expression of glucocorticoid receptor mRNA in rat hippocampus after traumatic brain injury
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摘要 目的研究创伤性脑损伤(TBI)后大鼠海马区糖皮质激素受体(GR)mRNA表达的变化及其对大鼠认知功能的影响。方法建立大鼠头颅侧向旋转加速脑创伤模型,应用逆转录酶-聚合酶链式反应(RT-PCR)和Morris水迷宫检测伤后大鼠海马区GR mRNA的表达与学习记忆功能的关系。结果伤后4～7 d大鼠海马区GR持续低表达;Morris水迷宫检测伤后大鼠出现认知功能障碍。结论 TBI大鼠海马区GR mRNA的降低影响大鼠认知功能。 Objective To explore the expression of glucocorticoid receptor（GR） mRNA in rat hippocampus and its effect on cognitive function after traumatic brain injury（TBI）.Methods The rat TBI model by lateral acceleration rotation of head was established.GR mRNA levels were detected by reverse transcription polymerase chain reaction（RT-PCR）,and cognitive function was evaluated by Morris water maze.Results Expression of GR mRNA in rat hippocampus remained in low level from 4 d to 7 d after TBI.Morris water maze test showed significant impairment of cognitive functions in rats.Conclusion Down-regulation of GR mRNA in hippocampus induces the cognitive dysfunction in rats.
作者 高伟 贺晓生 梁明 顼红雨
机构地区 第四军医大学西京医院神经外科
出处 《中华神经外科疾病研究杂志》 CAS 2011年第1期5-7,共3页 Chinese Journal of Neurosurgical Disease Research
关键词 创伤性脑损伤 海马 糖皮质激素受体 认知障碍 Traumatic brain injury Hippocampus Glucocorticoid receptor Cognitive dysfunction
分类号 R33 [医药卫生—人体生理学]
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参考文献15

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共引文献2

同被引文献20

  • 1张宁霞,陈慧娟,倪力强,童瑶.疏肝理肺法对应激条件下哮喘大鼠海马糖皮质激素受体mRNA表达的影响[J].上海中医药杂志,2005,39(3):48-51. 被引量：5
  • 2韩秀引,王蕾,马玉琼,欧可群,陈文玉.免疫刺激对大鼠海马CA2、3区nNOS和c-Fos表达的影响[J].解剖科学进展,2005,11(4):287-290. 被引量：1
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引证文献2

二级引证文献4

中华神经外科疾病研究杂志
2011年 第1期

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