摘要
目的建立双同位素标记试餐ＳＰＥＣＴ胃排空检测技术，研究健康志愿者固体、液体食物胃排空及胃内分布情况，探讨近端胃和远端胃在食物胃内分布和排空过程中的作用．方法９９ｍＴｃ植酸钠活体标记的鸡肝为固体试餐，含糖８０ｇ／Ｌ饮料２３０ｍＬ中加入１１３ｍＩｎＤＴＰＡ为液体试餐．１７例健康志愿者（男９例，女８例，年龄４５８岁±１４３岁）进食试餐后，平卧于带高能准直器的ＳＰＥＣＴ探头下，同步记录胃内两种同位素的活性变化，应用计算机程序划出全胃感兴趣区（ＲＯＩ）、近端胃ＲＯＩ和远端胃ＲＯＩ，提取同位素计数，拟合出液体和固体食物胃排空曲线，获得：①固体食物排空前的迟滞相（ｌａｇｔｉｍｅ，ＴＬ）；②固体和液体食物的近端胃半排空时间（ｐＴ５０）；③固体和液体食物的全胃半排空时间（Ｔ５０）；④远端胃内同位素最大活性（ＭＡＦ）及达到ＭＡＦ的时间（Ｔｍａｆ）．结果试餐标记物的稳定性良好．摄入试餐后液体成分很快开始排空，不存在ＴＬ，排空曲线呈指数曲线，Ｔ５０为４２ｍｉｎ±１０ｍｉｎ，ｐＴ５０为３９ｍｉｎ±１１ｍｉｎ，Ｔ５０与ｐＴ５０高度正相关（Ｐ＜００５），与远端胃内活性变化无显著相关型（Ｐ＞００５）．固体食物排空前有ＴＬ（平均?
AIM To establish the technique to test gastric emptying with dual isotope labeled test meals and SPECT, and evaluate intragastric distribution and gastric emptying of solid and liquid meals in healthy volunteers. METHODS 99mTcPHY living labeled chicken liver served as solid food and 80g/L glucose mixed with 113mInDTPA as liquid food. Seventeen healthy volunteers(9 male113mIn- and 8 female with mean age of 458143 yearsold) were studied.After digestion of the meals, activities of the two isotopes in different parts of gastric area(proximal and distal stomach)were read respectively with SPECT technique. The emptying curves could be derived and the emptying parameters were obtained: lag time(TL)before solid emptied, half emptying time for solid emptied from proximal part (pT50), half emptying time (T50)of solid or liquid emptied from the stomach, and maximal activities fraction in distal stomach (MAF) and the time to reach MAF(Tmaf). RESULTS Just after food intake, the liquid meal was quickly distributed from proximal to distal stomach and emptied with an exponential curve. T50 was 42min10min and pT50 39min11min. There was a good positive relationship between them (P<005). However, TL did not exist. In contrast, solid emptying showed a power exponential curve with a lag time in the initial phase. T50 was 70min16min and pT50 57min27min. There existed a positive relationship between T50 and either pT50 or Tmaf (P<001,respectively), and a negative relationship between T50 and MAF(P<005). CONCLUSION Liquid emptying was related with the motility of proximal stomach, while solid was governed by the coordinated contraction of proximal and distal parts. Both the proximal and distal parts of the stomach play important roles in controlling the intragastric distribution and emptying of solid meal. The SPECT technique was good for testing emptying function.
出处
《世界华人消化杂志》
CAS
1999年第7期564-566,共3页
World Chinese Journal of Digestology
关键词
胃排空
胃肠活动
同位素标记
gastric emptying
gastrointestinal motility
isotope labeling
