摘要
目的:探讨多层螺旋CT灌注成像评价临床Ⅰ期非小细胞肺癌(NSCLC)病理特征的价值。方法:对129例NSCLC患者行MSCT灌注扫描,采用多元相关分析探讨灌注参数与病理特征的关系,再分组进行趋势检验。结果:灌注参数与NSCLC病理特征具有相关性,高、中和低分化肿瘤的血流量(BF)值分别为(58.3±20.5)、(38.5±15.7)和(30.3±6.7)ml/(100g.min),强化峰值(PEI)分别为(26.1±11.7)(、23.6±6.9)和(16.2±4.9)HU,血流量和强化峰值随分化程度减低而降低(P值分别为0.01和0.023);有淋巴结转移组的BF[(28.4±9.8)ml/100g.min)]和PEI[(10.9±8.4)HU]明显低于无淋巴结转移组(分别为[(47.3±16.5)ml/(100g.min)和(24.0±8.7)HU],差异有极显著性意义(P值分别为<0.001和0.002);术后转移组BF值[(22.6±3.2)ml/(100g.min)]明显低于未转移组[(45.0±16.4)ml/(100g.min)],差异有极显著性意义(P<0.001);不同病理类型灌注参数的差异无显著性意义(P>0.05)。结论:MSCT灌注成像通过无创性评价血管生成的方式和程度,间接反映肿瘤分化程度,从而预测淋巴结转移和术后转移的可能性,是判断NSCLC生物学行为及预后的良好指标。
Objective：To discuss the role of multi slice spiral CT （MSCT） pulmonary perfusion imaging in the evaluation of clinical stage Ⅰ non-small cell lung cancer （NSCLC）. Methods： 129 patients with NSCLC had MSCT perfusion imaging. Correlation analysis was made between CT perfusion parameters and pathology characteristics. Trend tests were used for the comparison of different groups. Results：There was correlation between CT perfusion parameters and pathology features of NSCLC. The blood flow （BF）of well-, middle- and poorly differentiated carcinoma was （58.3 ± 20.5）, （38.5 ± 15.7） and （30.3±6.7）ml/（100g·min） respectively,the peak enhanced index （PEI） was （26. 1±11.7） ,（23.6±6.9） and （16.2±4.9）HU respectively,with the p value as 0.01 and 0. 023 respectively. The BF and PEI decreased with the decreasing of NSCLC differentiation grading. The BF value of NSCLC with lymph node metastasis was [（28. 4± 9.8）ml/（100g·min）] and the PEI was [（10.9±8.4）HU], which was obviously lower than that without lymph node metastases[（47.3±16.5）ml/（100gomin） and （24.0±8.7）HU] respectively,the p value was 0. 000 and 0. 002 respectively. The BF value of patients with post surgery metastases was [（22.6 ± 3.2）ml/（100g · min）], which was markedly lower than that with no metastasis [-（45.0 ± 16.4）ml/（100g· min）], with significant statistical difference （P〈0. 001）. No obvious differences were showed between the CT perfusion parameters of different pathology sub-types of NSCLC （P〉 0. 05）. Conclusion：The mode and degree of angiogenesis of NSCLC could be evaluated by MSCT perfusion imaging, which is a noninvasive approach, could indirectly reflect the grade of tumor differentiation and predict the possibility of lymph node metastases as well as postoperative metastasis. MSCT pulmonary perfusion imaging can be used as a useful marker to judge the biological behavior and the prognosis of NSCLC.
出处
《放射学实践》
北大核心
2010年第11期1224-1227,共4页
Radiologic Practice
关键词
肺肿瘤
非小细胞肺癌
病理
灌注成像
体层摄影术
X线计算机
Pulmonary neoplasms
Non-small cell lung cancer
Pathology
Perfusion imaging
Tomography,X-ray computed
