摘要
目的应用MR扩散张量成像(DTI)技术探讨MRI正常的额叶癫患者与运动相关白质是否存在隐匿性病变。方法对临床确诊的16例MRI正常的额叶癫患者发作间期和30例健康志愿者行常规MRI和DTI检查,定量测量额叶皮层下白质、胼胝体膝部和压部、内囊前肢和后肢及外囊的平均扩散系数(DCavg)和部分各向异性(FA)值,并进行统计学分析。结果 MRI正常的额叶癫患者额叶皮层下白质、胼胝体膝部区域的DCavg值显著高于正常人(P<0.01),皮层下白质的FA值显著低于正常人(P<0.01),胼胝体膝部的FA与正常人无差异。结论 MRI正常的额叶癫患者存在额叶隐匿性损害;DTI为发现致灶提供理论依据,具有临床应用价值。
Objective To investigate whether white matter correlating with movement has occult damage or not in patients with MRI-negative refractory frontal lobe epilepsy by diffusion tensor imaging （DTI）. Methods Sixteen patients with MRI- negative refractory frontal lobe epilepsy and 30 healthy volunteers received conventional and DTI scanning. The DCavg and FA of white matter structures correlating with movement （including frontal lobe white matter, genu and splenium of the corpus cal- losum, anterior and posterior limb of the internal capsule and external capsule） were measured respectively and data were taken into post-processing. Results In patients with MRI-negative refractory frontal lobe epilepsy, elevated DCavg was demonstrated in the frontal lobe whlte matter and in the genu of the corpus callosum（P〈0.01）, reduced FA was demonstrated in the frontal lobe white matter（P^0. 01）. Conclusion Patients with MRI-negative refractory frontal lobe epilepsy have occult damage in the frontal lobe white matter. DTI offer theoretical evidence in searching epileptogenic focus for the MRI-negative refractory frontal 10be epilepsy and have potential for clinical applications.
出处
《中国实用神经疾病杂志》
2010年第17期5-8,共4页
Chinese Journal of Practical Nervous Diseases
关键词
部分性发作癫
磁共振成像
扩散张量成像
MRI-negative refractory frontal lobe epilepsy
Nuclear magnetic resonance
Diffusion tensor imaging
